Markers of shaping and educating the early life immune response to food proteins

Food allergy has emerged over the past decade as an important public health concern, culminating in a second wave of the 'allergy epidemic' and thereby succeeding the first respiratory epidemic. Early-life events, environmental and lifestyle factors play a crucial role in the development of food allergies. The understanding of how those factors synergize in the breakdown of oral tolerance is vital for the foundation of future strategies of food allergy prevention. This study will address the mechanism of early-life events that are fundamental for shaping the immunological response to food antigens, studying food allergy and tolerance as a disease models, by longitudinal, deep immune and genomic profiling during early life from prebirth to infancy.

 

• Project PI Annette Kuehn

 

Project partners: Centre Hospitalier de Luxembourg (CHL), University of Luxembourg/ Luxembourg Centre for Systems Biomedicine (LCSB), Integrated Biobank of Luxembourg (IBBL), Megeno

Co-funding: FNR-PRIDE i2TRON DTU