The gut mucosa is one of the most critical barriers separating the human internal environment from the external milieu. The gastrointestinal tract represents the largest luminal interface between the body and the external environment. Defects of the intestinal barrier are thought to be linked to a broad range of intra- and extra-intestinal pathophysiologies, including food allergies. Barrier dysfunction represents the basis for a disturbed flux of foreign antigens across the epithelium leading to a window of opportunity for immunological tolerance breakdown and chronic inflammatory gut responses. The aim of this translational study is to address the correlation of clinical and immunological patient profiles with functional characteristics of the gut microbiome in order to unravel novel translational strategies for combating food allergies.
Project partners: Centre Hospitalier de Luxembourg (CHL), University of Luxembourg/ Luxembourg Centre for Systems Biomedicine (LCSB), Integrated Biobank of Luxembourg (IBBL)
Co-funding: FNR-PRIDE MICROH DTU