Advanced food allergen metabolism: from in-vitro to in-vivo peptides

Food allergies are a global burden leading to an important impact on the patient's situation and negative effects on both the society and economies. Classified as type-I hypersensitivity reactions, the most common food allergies are characterized by the synthesis of specific IgE-antibodies against otherwise harmless food proteins. Clinical phenotypes of food-allergic patients are highly diverse, such as by medical symptoms, symptoms severity, delay of reaction, threshold level reactivity and level of allergic cross-reactivity. In-vitro markers to predict clinical reactions remain largely unknown. The aim of this clinically oriented study is to identify phenotypic biomarker by comprehensive and deep profiling of a food-allergic cohort, in comparison to tolerant individuals, using a multi-omics analyses including food allergen metabolism aspects. Those insights will contribute to decipher the immune mechanisms underlying food-allergic reactions and pave the way towards novel personalized medicine approaches in the diagnosis and treatment of affected individuals.

 

• PhD thesis project Julia Klueber, Project PI Annette Kuehn

 

Project partners: Odense Research Center for Anaphylaxis (ORCA); Centre Hospitalier de Luxembourg (CHL); Technical University of Munich, Helmholtz Center Munich, Integrated BioBank of Luxembourg (IBBL)

Co-funding: FNR-PRIDE NextImmune DTU; Personalized Medicine Consortium (PMC) of Luxembourg